A three-year PhD fellowship is available in the clinical research project The DYNAMITE Trial investigating the effect of advanced Cardiac CT imaging on morbidity and mortality in patients with suspected or confirmed coronary artery disease

A three-year PhD position is open at the Department of Cardiology, Copenhagen University Hospital – Rigshospitalet, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen.

For decades the clinical consensus has been that a definite diagnosis of ischemic heart disease requires an invasive coronary angiography. Nevertheless, a shift of paradigm has been underway following the introduction of coronary CT angiography (CCTA). CCTA provides logistically simple, fast, and non-invasive visualization of coronary atherosclerosis. However standard CCTA does not offer functional assessment of coronary disease. Advanced technologies including CT fractional flow reserve (CT-FFR) and dynamic CT-perfusion imaging could substantially improve the clinical value of cardiac CT.

The purpose of the DYNAMITE trial (Dynamic CT stress myocardial perfusion, CT fractional flow reserve and coronary CT angiography for optimized treatment strategy in patients with chest pain syndromes, (clinical trials.gov identifier: NCT04709900) is to determine the ability of combined anatomical and functional cardiac CT imaging to improve morbidity and mortality in patients with suspected or known ischemic heart disease. The goal is to define the optimal evaluation and treatment strategy in this large group of patients.

About the position

The three-year PhD position is fully funded by a research grant from The Novo Nordisk Foundation. The PhD student will receive training in clinical research methods and cardiovascular imaging techniques. The PhD fellow will be part of an interdisciplinary and ambitious study team with expertise within medical imaging techniques, cardiology, and clinical research. The team includes non-invasive and invasive cardiologist, cardiac CT radiographers and cardiology research nurse specialists.

The candidate will be enrolled as PhD-student at the University of Copenhagen. The PhD-supervisor team consists of Ole Ahlehoff, Jesper J Linde, Lars Køber and Klaus Fuglsang Kofoed, (Faculty supervisor). The DYNAMITE trial is a collaboration between several institutions, including Department of Cardiology, Radiology and Thoracic surgery Rigshospitalet, in addition to Nordsjællands Hospital, Hillerød, Hvidovre-Amager Hospital, Glostrup Hospital, Herlev-Gentofte Hospital, Bispebjerg-Frederiksberg Hospital and Roskilde Hospital.

Responsibilities and tasks

• Contribute to recruitment of study participants, and communication with study participants
• Responsible for coordinating and conducting CT-scans at Rigshospitalet, including annotation and interpretation of CT-scan data
• Carry out scientific tasks related to the project, including CT image analysis in addition to project database data handling, statistical analyses, writing of scientific articles and other communication of results, in collaboration with the supervisors and other members of the project team.

Qualifications

We are looking for applicants with a Medical Degree and an interest in clinical cardiology or radiology with the following qualifications:

• Interest in learning cardiac imaging techniques
• Ability to work both independently and as part of a team
• Good communication skills in Danish and English, both written and orally
• Research experience including experience in writing and publishing scientific papers is an advantage
• Experience with statistics and programming in R or similar software is an advantage

Terms of employment

The position is full time and limited to 3 years. Salary and employment conditions are in accordance with the regional collective agreements. The starting date is March 1, 2023 (or the earliest available date, by mutual agreement).

Application

Your application must include the following:

• A letter motivating the application (cover letter, no longer than 1 page)
• Curriculum Vitae including (if available) references/recommendations and list of publications
• Diploma including grades
• Autorisations

Please submit the application with the required attachments. Only online applications will be accepted. Application deadline is Tuesday, January 30, 2023, at 23:59.

First round of interviews is expected to be held Wednesday, February 8, 2023.

If you have any questions about the position, please contact Clinical associated research professor Klaus Fuglsang Kofoed, MD, PhD, DmSc, E-mail: Klaus.Kofoed@Regionh.dk

Phone: +45 35458569 or +45 26807439

A three-year PhD position is open at the Department of Cardiology, Copenhagen University Hospital – Rigshospitalet, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen.

For decades the clinical consensus has been that a definite diagnosis of ischemic heart disease requires an invasive coronary angiography. Nevertheless, a shift of paradigm has been underway following the introduction of coronary CT angiography (CCTA). CCTA provides logistically simple, fast, and non-invasive visualization of coronary atherosclerosis. However standard CCTA does not offer functional assessment of coronary disease. Advanced technologies including CT fractional flow reserve (CT-FFR) and dynamic CT-perfusion imaging could substantially improve the clinical value of cardiac CT.

The purpose of the DYNAMITE trial (Dynamic CT stress myocardial perfusion, CT fractional flow reserve and coronary CT angiography for optimized treatment strategy in patients with chest pain syndromes, (clinical trials.gov identifier: NCT04709900) is to determine the ability of combined anatomical and functional cardiac CT imaging to improve morbidity and mortality in patients with suspected or known ischemic heart disease. The goal is to define the optimal evaluation and treatment strategy in this large group of patients.

About the position

The three-year PhD position is fully funded by a research grant from The Novo Nordisk Foundation. The PhD student will receive training in clinical research methods and cardiovascular imaging techniques. The PhD fellow will be part of an interdisciplinary and ambitious study team with expertise within medical imaging techniques, cardiology, and clinical research. The team includes non-invasive and invasive cardiologist, cardiac CT radiographers and cardiology research nurse specialists.

The candidate will be enrolled as PhD-student at the University of Copenhagen. The PhD-supervisor team consists of Ole Ahlehoff, Jesper J Linde, Lars Køber and Klaus Fuglsang Kofoed, (Faculty supervisor). The DYNAMITE trial is a collaboration between several institutions, including Department of Cardiology, Radiology and Thoracic surgery Rigshospitalet, in addition to Nordsjællands Hospital, Hillerød, Hvidovre-Amager Hospital, Glostrup Hospital, Herlev-Gentofte Hospital, Bispebjerg-Frederiksberg Hospital and Roskilde Hospital.

Responsibilities and tasks

• Contribute to recruitment of study participants, and communication with study participants
• Responsible for coordinating and conducting CT-scans at Rigshospitalet, including annotation and interpretation of CT-scan data
• Carry out scientific tasks related to the project, including CT image analysis in addition to project database data handling, statistical analyses, writing of scientific articles and other communication of results, in collaboration with the supervisors and other members of the project team.

Qualifications

We are looking for applicants with a Medical Degree and an interest in clinical cardiology or radiology with the following qualifications:

• Interest in learning cardiac imaging techniques
• Ability to work both independently and as part of a team
• Good communication skills in Danish and English, both written and orally
• Research experience including experience in writing and publishing scientific papers is an advantage
• Experience with statistics and programming in R or similar software is an advantage

Terms of employment

The position is full time and limited to 3 years. Salary and employment conditions are in accordance with the regional collective agreements. The starting date is March 1, 2023 (or the earliest available date, by mutual agreement).

Application

Your application must include the following:

• A letter motivating the application (cover letter, no longer than 1 page)
• Curriculum Vitae including (if available) references/recommendations and list of publications
• Diploma including grades
• Autorisations

Please submit the application with the required attachments. Only online applications will be accepted. Application deadline is Tuesday, January 30, 2023, at 23:59.

First round of interviews is expected to be held Wednesday, February 8, 2023.

If you have any questions about the position, please contact Clinical associated research professor Klaus Fuglsang Kofoed, MD, PhD, DmSc,

E-mail: Klaus.Kofoed@Regionh.dk 

Phone: +45 35458569 or +45 26807439

• Fakta

• Arbejdssted
  Rigshospitalet
• Kontaktperson
  Klaus Fuglsang Kofoed
• Adresse
  Blegdamsvej 9, 2100 København Ø
• Stillingstype
  Forsker
• Speciale
  Arbejdsmedicin
• Ansættelsesform
  Uddannelsesstilling – tidsbegrænset ansættelse
• Ugentlig arbejdstid
  Fuld tid
• Ansættelsens start
  01-03-2023
• Regionens jobnr.
  246531
• Quick-nr.
  442301
• Indrykningsdato
  30-12-2022
• Ansøgningsfrist
  30-01-2023 (udløbet)